Third dose of Pfizer vaccine boosts antibodies up to 11-fold against the Indian ‘Delta’ variant as study finds efficacy of standard two shots drops to 84% after six months
- Pfizer released trial data for the third dose of the company’s COVID-19 vaccine during an earnings call Wednesday
- Pre-print study data finds that efficacy of Pfizer vaccine falls from 96 percent to 84 percent after six months
- Third dose can increase antibody levels 11-fold for the Delta variant for those aged 65 to 85
- Company plans to apply for emergency use authorization as early as August
- Pfizer is also working on a Delta variant specific vaccine that may begin clinical trials as early as next month
A third dose of the Pfizer-BioNTech COVID-19 vaccine could offer strong protection against the Indian ‘Delta’ variant, data reveals, as a separate study finds protection provided by the vaccine could wane after six months.
New data released by the company on Wednesday showed antibody levels increased five-fold among people ages 18 to 55 who were given the booster shot.
The third dose was especially effecting for the elderly, with antibody levels spiking 11-fold among people aged 65 to 85 who had already received the standard two doses.
In the slides published online, the researchers wrote there there is ‘estimated potential for up to 100-fold increase in Delta neutralization post-dose three compared to pre-dose three.’
The new data comes at a welcome time, as separate pre-print research finds that the efficacy of the Pfizer vaccine falls from 96 percent to only 84 percent after six months.
Data from Pfizer shows that the third dose of the company’s COVID vaccine can increase antibodies to fight the Delta variant 11-fold in people 65 to 85
The Delta variant continues to spread across the country, making up at least 83 percent of all new infections.
Pfizer produces the most commonly used vaccine in the U.S., having been administered over 190 million times, according to data from the Centers for Disease Control and Prevention (CDC).
The company plans to submit its application for emergency use authorization for the third dose to the U.S. Food and Drug Administration as early as August, according to slides distributed before an earnings call.
Clinical studies on a Delta variant-specific vaccine may begin soon as well.
Pending regulatory approval, the company plans to kick off trials in August, and has even already produced the first batch of the vaccine to be used.
Rumbles about the potential for a third dose in the near future have been happening for months.
Dr Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, has said in the past that he expects a third dose to be needed in the coming months.
Though, he said earlier this month that he does not expect booster shots to be needed for the fully vaccinated at this time.
Fauci said earlier this week, though, that those who are vulnerable to the virus even after vaccination still may require a third dose.
Some elderly people, and people with conditions like cancer or who have received an organ transplant, are found to have not developed the sane antibody levels as others post vaccine.
Pfizer is also working on a vaccine specific to combatting the Delta COVID-19 variant, according to documents distributed as part of their earnings call
The Delta variant has also shown a rare ability to cause breakthrough cases among fully vaccinated people.
The ability to cause breakthrough cases was cited by the Centers for Disease Control and Prevention as the reason for the reintroduction of masks for fully vaccinated people in some parts of the country.
If Pfizer’s findings – which are not peer-reviewed – are correct, then the third dose could be a valuable tool in combatting the variant.
The company’s findings also found that a third dose could be particularly effective in combating the South African Beta variant.
The variant accounts for less than 10 percent of active cases in the United States.
Pfizer also revealed on the earnings call that they are working on a flu vaccine that uses the same mRNA technology used to develop its COVID vaccine.
Moderna, who also developed an mRNA COVID vaccine, began trials of an mRNA flu vaccine at the start of the month.